Rnqlp protein

PIN is the prion of the nonessential protein Rnqlp (Derkatch et al., 2001). The cellular function of Rnqlp is not entirely clear Rnqlp can be knocked out without influencing cell viability (Sondheimer and... 

Rnql Rnqlp [PIN] or [PIN -] Mutant allele Full-length protein Prion genotype, causes [PS/]-inducing ability... 

The prion domains of Ure2p, Sup35p, and Rnqlp have unusual amino acid compositions, with abnormally high contents of the polar uncharged residues, Asn and Gin, and relatively low contents of charged and hydrophobic amino acids. In contrast, the amino acid composition of the HET-s prion domain is more typical of a normal globular protein. 

A third yeast prion, PIN, is similar in some respects, but its non-prion domain—in this case, the N-terminal part of the molecule—has no established cellular function. The protein Rnqlp is a gain-of-function prion whose activity is expressed via its ability to induce [PS/]. [PIN] forms much more readily than the other two prions, and [PIN] cells induce [PSI] under... 

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