Risperidone Reboxetine

In a study of patients with schizophrenia or schizoaffective disorder, co-administration of reboxetine 8 mg/day did not affect the plasma levels of either ciozapine or risperidone. 

Spina E, Avenoso K Scordo MG, Ancione M, M dia A, Levita A. No effect of reboxetine on plasma concentrations of clozapine, risperidone, and their active metabolites. Ther Drug Monit 200 )73,675-8. 

No clinically relevant pharmacokinetic interaction appears to occur between risperidone and reboxetine. 

Reboxetine 8 mg daily was given to 7 schizophrenic patients taking risperidone 8 mg daily for a period of 3 weeks. Reboxetine had no significant effects on the pharmacokinetics of either risperidone or its active metabolite, 9-hydroxyrisperidone, suggesting that no additional precautions are necessary if reboxetine and risperidone are used together. ... 

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