Ring systems macrocyclic reactions

The high stability of porphyrins and metalloporphyrins is based on their aromaticity, so that porphyrins are not only most widespread in biological systems but also are found as geoporphyrins in sediments and have even been detected in interstellar space. The stability of the porphyrin ring system can be demonstrated by treatment with strong acids, which leave the macrocycle untouched. The instability of porphyrins occurs in reduction and oxidation reactions especially in the presence of light. The most common chemical reactivity of the porphyrin nucleus is electrophilic substitution which is typical for aromatic compounds. 

Intramolecular Friedel-Crafts acylation has been observed with bonellin dimethyl ester (20).53 The reaction proceeds in contrast to corresponding porphyrins, very smoothly with concentrated sulfuric acid because the propanoic acid side chain at the sp3 center is located above the macrocyclic ring system and therefore can better fulfill the stereoelectronic requirements for the ring-closure reaction. The ring closure is accompanied by racemization in the product 21. 

By reaction of 2-alkyl-4,6-dichloro-l,3,5-trimethylborazines (alkyl = methyl, ethyl, i-propyl) with bis(trimethylsilyl)amine the tetrameric borazine ring systems 4-6 are produced (Fig. 2) they can be purified by several successive vacuum sublimations (yields 4-60%). If the borazines carry n-propyl and tert-butyl groups in the 2-position or if methylbis(trimethylsilyl)amine is used to bridge the borazine molecules, the macrocyclic ring formation is inhibited [17, 18]. 

As for the biaryl ether containing macrocycles, an array of bioactive macrocycles with an endo aryl-aryl bond exist in nature. A new palladium catalyzed reaction has been recently developed in which bis(pinacolato)diborane(4) mediated the process to reach such a structural motif. The reaction consists of a domino process involving a Miyaura s arylboronic ester synthesis and an intramolecular Suzuki-coupling. Synthesis of a bicyclic A-B-O-C ring system of RP-66453 273, a neurotensine receptor antagonist, with an endo aryl-aryl and an endo aryl-aryl ether bond was described (Scheme 53).141... 

Griesbeck et al. have developed the decarboxylative photocyclization (PDC) of phthalimido oo-alkylcarboxylates (15) as a versatile route to macrocyclic ring systems (16). The carboxylate serves as electron donor and C02 is eliminated during the course of the reaction. Applying this concept, the syntheses of medium- and macrocyclic amines, polyethers, lactams, lactones, as well as cycloalkynes were accessible but the limitations... 

The enhanced reaction rates and regioselectivities (head-to-head) in the alkene dimerisation (cyclobutane formation e.g. 18-19) via radical cation catalysed reactions have led numerous studies in this direction [5,10, 36-39]. The head-to-head stereochemistry of these dimerisations have been explained in terms of the addition of the radical cation to a neutral molecule giving the stabilised 1,4-radical cation. An interesting application of the cation-radical initiated (2 + 2)-cyclodimerisation strategy was reported by Mizuno et al. [40] for the synthesis of macrocyclic 2-m-dioxabicyclo (m-1,2,0) ring systems (21) from the PET reactions of 20 (Scheme 6). 

Several detailed investigations of transannular IMDA cycloadditions have appeared in recent years. This transformation promises to become an important synthetic method owing to the potential for the rapid efficient construction of complex polycyclic ring systems. Other potenti strategic benefits include increased reactivity due to diminished entropic requirements (AS ). This is nicely illustrated by the facile cyclization of (101) with a tetrasubstituted dienophile, compared with the unsuccessful IMDA reaction of (102) (Figure 27). Although the cyclization of (101) proceeds with only moderate diastereoselection, many other examples have been reported that exhibit outstanding selectivity, e.g. cyclization of (103). It is conceivable that conformational constraints imposed by the macrocyclic system may lead to improved IMDA stereoselectivity relative to conventional acyclic trienes, but this point has not yet been demonstrated in any published examples. 

Intramolecular photocyclization between the vinyl moieties of (189) occurs using 9,10-dicyanoanthracene as an electron transfer sensitizer. In general, the route leads to the moderately efficient synthesis of the macrocyclic ring system (190, 191). The stereoselectivity shown by the reaction is, in some instances, dependent on the solvent used. Thus with (189a, b, and c), the cis-isomers (190) were the major products with acetonitrile as solvent, but with benzene the frans-isomer (191) predominated. In the case of (189d, e, and f), the trans-isomers predominate with both solvents. 

From a synthetic point of view, bond forming steps are the most important reactions of radical ions [202]. Several principle possibilities have been described in Section 8.1 and are summarized in Scheme 52. Many carbo- and heterocyclic ring systems can be constructed by (inter- and intramolecular) radical addition to alkenes, alkynes, or arenes. Coupling of carbonyl radical anions leads to pinacols either intra-or inter-molecular which can be further modified to give 1,2-diols, acyloins or alkenes. Radical combination reactions with alkyl radicals afford the opportunity to synthesize macrocyclic rings. These radical ion-radical pairs can be generated most efficiently by inter- or intramolecular photoinduced electron transfer. 

---