Ring-closing metathesis reaction aromatic rings

In addition to ring-closing metathesis, nucleophilic aromatic substitution and Heck coupling reactions can also be used to efficiently form cyclic peptides using microwave irradiation. 

On the basis of the original studies [111-113], the DoM-cross-coupHng sequence represents a significant entry into chiral binaphthol (BINOL) and achiral biphenol (BIPOL) ligands (Table 14.18) [111-119], which are outside the scope of this review but are widely used for enantioselective reactions, for example, Et2Zn addition to aromatic aldehydes, the Mannich-type reactions, and the Diels-Alder as well as asymmetric ring-closing metathesis (ARCM) reactions. 

Recently, 4 was reported to be an excellent catalyst for the enantioselective substitution of Morita-Baylis-Hillman carbonates with allylamines [21]. Only carbonates with an aromatic group gave the desired enantioenriched N-allyl-P-amino-methylene esters (Scheme 6.6). Ring-closing metathesis of the products of the allylation reaction was shown to result in chiral 2,5-dihydropyroles of importance as starting materials for the synthesis of products of biological and medical interest. 

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