Sertraline rifampicin

Clinically important, potentially hazardous interactions with aprepitant, astemizole, carbamazepine, colchicine, cyclosporine, dihydroergotamine, ergot alkaloids, ergotamine, erythromycin, fluoxetine, fluvoxamine, methylprednisolone, methysergide, oral contraceptives, paroxetine, pimozide, prednisolone, rifampicin, sertraline, solifenacin, terfenadine, warfarin... 

In two isolated cases rifampicin decreased the efficacy of citalo-pram and sertraline. 

Both sertraline and citalopram are metabolised by cytochrome P450 isoenzymes including CYP3A4 and rifampicin is a potent inducer of the hepatic CYP450 system, particularly CYP3A4. It would therefore appear that rifampicin induced the metabolism of these two drugs resulting in... 

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