Ribosyl 2-deoxy

Adenine, 9- -D-2-deoxyribofuranosyl-, 5, 536 Adenine, 8-(2-deoxy-/3-D-ribosyl)-synthesis, 5, 585 Adenine, 2,8-dialkyl-synthesis, 5, 569 Adenine, 2,8-dichloro-reactions... 

Deoxy-D-ribose 5-phosphate 2-deoxy-D-ribosyl phosphate (1)... 

Deoxy-a-D-ribosyl-l-phosphate 20, a key substrate in the preparation of 2 -deoxynucleosides, was stereoselectively prepared by crystallization-induced asymmetric transformation in the presence of an excess of ortho-phosphoric acid and tri( -butyl)amine under strictly anhydrous conditions (Scheme 2).7 Initial Sn2 displacement of Cl in ot-glycosyl chloride 16 by phosphoric acid resulted in a 1 1 a/p anomeric mixture of 17 and 18 due to the rapid anomerisation of the a-chloride in polar solvents. Under acidic conditions, in the presence of an excess of H3P04, an equilibration between the a and p anomers gradually changed in favour of the thermodynamically more stable a-counterpart. By selective crystallization of the mono tri( -butyl)ammonium salt of the a-phosphate from the mixture, the equilibrium could be shifted towards the desired a-D-ribosyl phosphate 18 (oc/p = 98.5 1.5), which was isolated as bis-cyclohexylammonium salt 19 and deprotected to furnish compound 20. 

This enzyme [EC 2.4.2.6] catalyzes the reaction of 2-deoxy-D-ribosyl-base with base to produce 2-deoxy-o-... 

This enzyme [EC 5.3.1.24], also known as /V-(5 -phos-phoribosyl)anthranilate isomerase, catalyzes the interconversion of /V-(5-phospho-/3-D-ribosyl)anthranilate and l-(2-carboxyphenylammo)-l-deoxy-D-ribulose 5-phosphate. In some organisms, this enzyme is part of a multifunctional protein, together with one or more components of the system for the biosynthesis of tryptophan (anthranilate phosphoribosyltransferase, indole-3-glycerol-phosphate synthase, anthranilate synthase, and tryptophan synthase). 

For a ribosyl derivative if the sugar is deoxyribose, these names are prefixed by deoxy-, i.e., deoxycytidine. However, by custom, thymidine and thymidylic acid always refer to the deoxy derivative. 

Amino-l -(2,2-difluoro-2-deoxy-ribosyl)-2-oxo- ElOa, 11 (iyFNMR)... 

The 3-amino-3-deoxy-/3-D-ribosyl residue occurs in puromycin (Stylo-... 

Elementary analyses indicated that the sugar moieties of pyrimidine nucleosides derived from deoxyribonucleic acid are also of the deoxypen-tosyl type. Early attempts to apply the hydrogenation procedure of Levene and LaForge60 were unsuccessful. It was generally assumed, however, that the sugar portion of the pyrimidine nucleosides of deoxyribonucleic acid is probably also of the 2-deoxy-D-ribosyl type. 

An example which supports the trans rule is the condensation of 2,5-di-0-benzoyl-3-deoxy-3-phthalimido-/3-D-ribosyl chloride, a glycosyl halide containing the Cl-C2-trans structure, with mercuri derivatives of certain purines only nucleosides of the /3-d type are obtained.202 227... 

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