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Ribosomal protection

Fig. 4. Comparison of the three types of tetracycline resistance where T represents the tetracycline molecule O, a tetracycline transporter and aaa/, the ribosome A shows the effect of tetracycline exposure on a sensitive cell B, the efflux of resistance where a cytoplasmic membrane protein ( D) pumps tetracycline out of the cell as fast as the tetracycline transporter takes it up C, the ribosomal protection type of resistance where the ribosome is modified by ( ) to block productive binding and D, the tetracycline modification type of resistance where t is an inactive form of tetracycline. Reproduced with... Fig. 4. Comparison of the three types of tetracycline resistance where T represents the tetracycline molecule O, a tetracycline transporter and aaa/, the ribosome A shows the effect of tetracycline exposure on a sensitive cell B, the efflux of resistance where a cytoplasmic membrane protein ( D) pumps tetracycline out of the cell as fast as the tetracycline transporter takes it up C, the ribosomal protection type of resistance where the ribosome is modified by ( ) to block productive binding and D, the tetracycline modification type of resistance where t is an inactive form of tetracycline. Reproduced with...
M ribosomal protection Neisseria, Mycoplasma, Ureaplasma, Haemophilus, Campylobacter, Clostridium, Enterococcus, Staphylococcus, Streptococcus Gardnerella, Kingella, Eikenella, Veillonella, Tusobacterium, Peptostreptococcus Clostridium difficile. Streptococcus pneumoniae... [Pg.182]

O ribosomal protection Campylobacter, Lactobacillus, Streptococcus Enterococcus, Peptostreptococcus ... [Pg.182]

Resistance to tetracyclines is often caused by the acquisition of genes (e.g. tetO and tetM) coding for so-called ribosome protection proteins. These proteins bind to the ribosome and protect them from tetracycline action. [Pg.774]

Plasmid- or transposon-encoded ribosomal protection factors are a second mechanism of resistance to the tetracyclines. These proteins are believed to alter the tetracycline binding site on the 308 ribosomal subunit, lowering the affinity for the drugs. [Pg.190]

Ribosome protection (tetM gene) inactivating tetracyclines... [Pg.1054]

Parts of the 2569-nucleotide sequence for the RNA of phage MS2498 are shown in Fig. 29-17. The 5 end (upper left center) still bears the triphosphate group of the initiating GTP. Following a number of hairpin loops there is a ribosome-protected region, which begins with the initiation codon GUG for the A protein... [Pg.1714]

Three mechanisms of resistance to tetracycline have been described (1) decreased intracellular accumulation due to either impaired influx or increased efflux by an active transport protein pump (2) ribosome protection due to production of proteins that interfere with tetracycline binding to the ribosome and (3) enzymatic inactivation of tetracyclines. The most important of these is production... [Pg.1058]

Ribosomal protection Tetracyclines Transposon-specified tetracycline-resistant determinants (letM, tel0), cytoplasmic proteins acting in conjunction with ribosomes... [Pg.159]

Plasmid/transposon-encoded ribosomal protection factors Ribosomal protection is a mechanism in which a cytoplasmic protein interacts with the ribosome so that the latter becomes insensitive to inhibition by tetracyclines. Several classes of ribosomal protein resistant genes have been characterized, namely /erM, tetO and tetQ [193, 194]. The tetM deter-... [Pg.168]

Connell SR, Tracz DM, Nierhaus KH, Taylor DE. Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrob. Agents Chemother. 2003 47(12) 3675-3681. [Pg.102]

Trieber CA, Burkhardt N, Nierhaus KH, Taylor DE. Ribosomal protection from tetracycline mediated by Tet(O) Tet(O) interaction with ribosomes is GTP-dependent. Biol. Chem. 1998 379(7) 847-855. [Pg.102]

Resistance is widespread and often is indncible. The three main resistance mechanisms are (1) decreased accumulation of tetracycline (decreased antibiotic influx or acquisition of an energy-dependent efflux pathway) (2) production of a ribosomal protein that displaces tetracycline from its target, a protection that also may occur by mutation and (3) enzymatic inactivation of tetracyclines. Cross-resistance amongst tetracyclines depends on which mechanism is operative. Tetracycline resistance due to a ribosomal protection mechanism produces cross-resistance to doxycycUne and minocycline because the target site protected is the same for all tetracyclines. [Pg.762]

Resistance to macrolides can result from (1) drug efflux by an active pump mechanism (2) ribosomal protection by inducible or constitutive production of methylase enzymes that modify the ribosomal target and decrease drug binding (3) macrolide hydrolysis by esterases produced by Enterobacteriaceae and (4) chromosomal mutations that alter a SOS ribosomal protein (found in B. subtilis, Campylobacter spp., mycobacteria, and gram-positive cocci). [Pg.771]

Nikolich MP, Shoemaker NB, and Salyers AA. A Bacteroides tetracycline resistance gene represents a new class of ribosome protection. Antimicrob Agents Chemother 1992 36 1005-1012. [Pg.678]

The absence of 5 -proximal sequences in both eIF-2 and. ribosome-protected segments of mengovirus RNA (Perez-Bercoff and Kaempfer, 1982) supports the concept that the RNA of this virus has evolved a highly efficient mechanism of initiation that bypasses the need for either a 5 end or a 5 -terminal cap structure. Conceivably,... [Pg.153]

See other pages where Ribosomal protection is mentioned: [Pg.182]    [Pg.356]    [Pg.1005]    [Pg.1009]    [Pg.131]    [Pg.1063]    [Pg.343]    [Pg.211]    [Pg.226]    [Pg.226]    [Pg.227]    [Pg.182]    [Pg.692]    [Pg.777]    [Pg.127]    [Pg.680]    [Pg.17]   
See also in sourсe #XX -- [ Pg.356 ]



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