Rhamnogalacturonan core

Already in 1988 and 1991, Gao et al. [65,66] detected four different polysaccharides present in the leaves of Panax ginseng that had an effect on the complement system, but only two of them, the neutral, GL-NIa, and one of the acidic ones, GL-AIa, had potent activities at low concentrations. GL-NIa was found to be mainly an arabinigalactan type II polymer. GL-AIa was a polysaccharide with a rhamnogalacturonan core with neutral side chains of the AG-II type, confirmed by a strong reaction with the Yariv reagent and the methylation results. It was shown that the crude polysaccharide fraction contained KDO and DHA, suggesting the presence of Rhamnogalacturonan II in... 

The aerial part of sage was successively extracted with water, potassium oxalate, DMSO and KOH, and gave rise to different fractions with bioactivity. Partial purification of the water extract gave rise to a polydisperse fraction called A, that based on the monosaccharide composition, IR, and NMR, was thought to be composed of arabinogalactans associated with the highly ramified rhamnogalacturonans core. Fracfion B, exfracfed wifh oxalate, was... 

Some other anti-complementary acidic pectic arabinogalactans including rhamnogalacturonan core and arabinan have also been isolated from medicinal herbs such as the roots of Angelica acutiloba (AGIIb-1) [24-27], berries of Viscum album (Fig. 2) [29], and the roots of Urtica dioica [51]. Their arabinogalactan parts were also characterized as arabino-p-3,6-galactan. 

Modes of substitutions [R and R2] of the neutral side chains to the rhamnogalacturonan core were suggested from the results of base-catalyzed p-elimination [57]. 

Pectic polysaccharide, AR-4E-2, isolated from the roots of A, acutiloba showed a potent anti-tumor activity against the ascitic form of sarcoma-180, IMC carcinoma, and Meth A fibrosarcoma as well as the solid form of MM-46 tumor [90]. AR-4E-2 contained a rhamnogalacturonan core, and highly branched 3,5-arabinan and... 

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