Rh-Catalyzed Synthesis of Nitrogen-Containing Heterocycles

In this context, some important coupling reactions have been investigated for the formation of Af-heterocycles. These reactions provide easy access to various Af-heterocycles in high yields with different substitution patterns, but their substrate scope is limited by the need for prefunctionalization [2]. Transition metal-catalyzed C-H bond functionalization is an efficient alternative approach for the synthesis of Af-heterocycles that avoids preactivation of the substrates and reduces the number of synthesis steps. As such several current reviews on the synthesis of Af-heterocyclic compounds by transition metal-catalyzed C-H activation have been compiled [3]. 

Recently, a large number of novel transformations that involve rhodium (Rh)-catalyzed C-N bond-forming reactions have been developed for the construction of different Af-heterocyclic rings. Such transformations frequently occur with high stereoselectivity and a broad array of substrates under mild conditions. Selection of a suitable catalyst for a preferred substrate can seem intimidating. However, a rational solution to this problem can be delivered considering the possible mechanistic cycles for the individual transformations. 

Transition Metal-Catalyzed Heterocycle Synthesis via C—H Activation, First Edition. Edited by Xiao-Feng Wii. 2016 )C iley-VCH Verlag GmbH Co. KGaA. Published 2016 by Wiley-VCH Verlag GmbH Co. KGaA. 

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