RFLPs haplotype

In the analysis of family pedigrees it is usually possible by inspection of RFLP markers to phase or assign each to a specific chromosome. The array of RFLPs constitutes a haplotype unique to that chromosome. For many disorders, even those for which multiple mutations have been defined, within a given population or ethnic group a few specific mutations usually predominate (14). Generally each is associated with a distinctive haplotype of 2 or more RFLP markers. For example, functionally identical intervening sequence 1 splice site mutations in individuals of Mediterranean and Indian bacl round carry completely different RFLP haplotypes (13). Similarly, two RFLP markers proved use-... 

There has been few studies of MHC in other avian species, but there is evidence for linkage between MHC and blood groups in turkeys and ring-necked pheasants (Lamont Dietert, 1990). Four turkey class II genotypes have been identified, using RFLP and a domestic fowl DNA probe. Turkey erythrocytes appear either not to express class I proteins, or to express only very low levels (Emara et al, 1992). At least three class II B haplotypes and, therefore, six genotypes exist in ring-necked pheasant (Wittzell et al, 1994). 

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