Retroviral activity

Pope, M. T. Muller, A. (eds). Polyoxometalates From Platonic Solids to Anti-Retroviral Activity . Kluwer, Dordrecht, 1994. 

R. G. Finke in Polyoxometalates From Platonic Solids to Anti-Retroviral Activity, M. T. Pope and A. Muller, Eds., Kluwer, Dodrecht, 1994, pp. 267-280. (This monograph is Vol. 10 of Topics in Molecular Engineering, J. Maruani, Ed.)... 

M T. Pope and A. Muller, Angew. Chem. Int. Ed. Engl. 1991, 30, 34 Polyoxometallates From Platonic Solids to Anti-Retroviral Activity, Kluwer Academic Publishers, Dorderecht, The Netherlands, 1994 M T. Pope, Prog. Inorg. Chem. 1991,39, 81. 

Dideoxynucleosides show potent anti-retroviral activity against HIV-specific reverse transcriptase80-83. In particular, 2, 3 -dideoxy-3 -C-cyano-2 -substituted thymidine derivatives (33 A and 33 B) with a free 5 -hydroxy function (R1 = H) are potential inhibitors of the HIV-reverse transcriptase-promoted c-DNA synthesis. As these compounds have yet to be prepared by another method, the 3 -ene-nitrile 3284 was subjected to conjugate addition reactions with ammonia, primary amines, secondary amines and carbon nucleophiles. Most of these nucleophilic amine addition reactions give either the trans-isomer 33 A as the sole product (e.g., reaction with pyrrolidine, piperidine, morpholine), or as the major product along with the c/s-isomer (e.g., reaction with methylamine, benzylamine), except for the reaction with ammonia where the cts-isomer 33B is formed as the major product84. 

Polyoxometalates From Platonic Solids to Anti-retroviral Activity 1994 Polyoxoanions... 

Kozik, M. Baker, L. C. W. Blue Electron Distributions in Diamagnetic Reduced Heteropolytungstates. Insights Concerning Conduction Pathways and Spin Coupling Patterns. 183W NMR Chemical Shift Calculations. In Polyoxometalates from Platonic Solids to Anti-retroviral Activity Pope, M. T. Muller, A., Eds. Kluwer Academic Publishers Dordrecht, 1994, pp 191-202. 

M.T. Pope and A. Muller, eds (1994) Polyoxometalates From Platonic Solids to Anti-retroviral Activity, Kluwer Academic Publishers, Dordrecht. 

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