Retrospective detection

Polhuijs, M., Langenberg, J.P., and Benschop, H.P. (1997). New method for retrospective detection of exposure to organophosphorus anticholinesterases application to alleged sarin vicitims of Japanese terrorists. Toxicol. Appl. Pharmacol., 146, 156-161. 

Noort, D., Fidder, A., Hulst, A.G., Wooffitt, A.R., Ash, D., and Barr, J.R. (2004). Retrospective detection of exposure to sulfur mustard improvements on an assay for liquid chromatography-tandem mass spectrometry analysis of albumin-sulfur mustard adducts. J. Anal. Toxicol., 28, 333-338. 

In the third part, methods for retrospective detection of exposure to toxic scheduled chemicals using mass spectrometric and immunochemical analysis methods are discussed. The described methods are applied to human origin samples. These methods are essential when in cases of use, or allegations of use, previous presence or absence of toxic chemicals need to be confirmed. Identification of CWC-related chemicals provides key supporting evidence of noncompliance with the CWC. 

Langenberg, Retrospective detection of exposure to organophosphorus anticholinesterases mass spectrometric analysis of phosphylated human butyrylcholinesterase, Chem. Res. Toxicol., 15, 582-590 (2002). 

Methods for the Retrospective Detection of Exposure to Toxic Scheduled Chemicals. Part A Analysis of Free Metabolites... 

A. Fidder, D. Noort, A.G. Hulst, R. De Ruiter, M.J. Van der Schans, H.P. Benschop and J.P. Langenberg, Retrospective detection of exposure to organophosphorus anti-cholinesterases mass spectrometric analysis of phosphylated human butyrylcholinesterase, Chem. Res. Toxicol., 15, 582-590 (2002). 

Methods for the Retrospective Detection of Exposure to Toxic Scheduled Chemicals. 

Noort, D., Benschop. H.P., de Jong, L.P.A. (2001). Methods for retrospective detection of exposure to toxic scheduled chemicals an overview. Voj. Zdrav. Listy 70 14-17. 

Black RM, Noort D. Methods for the retrospective detection of exposure to toxic scheduled chemicals. Part A analysis of free metabohtes. In Mesilaakso M, ed. Chemical Weapons Convention Chemicals Analysis Sample Collection, Preparation, and Analytical Methods. Chichester, West Sussex, England John Wiley Sons 2(K)5 4()3 431. 

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