Retinopathy, diabetic vitamin

ARCSd 6 yr 1353 M-F No relation between diabetic retinopathy and intake of vitamin E and C from food and from food and supplements combined. (207)... 

Millen AE, Klein R, Folsom AR, et al, Relation between intake of vitamin C and E and risk of diabetic retinopathy in the Atherosclerotic Risk in Communities Study, Am J Clin Nutr 2004 79 865-873. 

In a related study, streptozotocin-induced diabetic rats were treated with pyridox-amine, vitamin E, and enalapril (7V-(l-[ethoxycarbonyl -3-phcny I propyl)-Ala-Pro), an AGE/ALE inhibitor, an antioxidant, and an ACE-inhibitor, respectively.598 Diabetic hyperglycaemia was accompanied by severe dyslipidaemia. Treatment with pyridoxamine was the most effective in reducing lipid abnormalities and in retarding nephropathy, retinopathy, and protein modification. Vitamin E was the next most effective treatment in retarding nephropathy, but did not affect retinopathy or AGE/ALE formation. Enalapril normalised blood pressure and retarded nephropathy and the accumulation of CML in the kidney, but did not affect dyslipidaemia and retinopathy. Thus pyridoxamine is the most effective therapy overall. 

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