Retina sildenafil

In theory, it should be possible to further augment the effect of sildenafil with nitrate drugs, shouldn t it However, this cannot be recommended - it has been tried and resulted in heart attacks. Sildenafil may also cause disturbances of colour vision this is due to the role of cGMP-gated channels in the excitation of the sensory cells of the retina. 

Sildenafil has weak inhibitory effects on phosphodiesterase type V in the retina, leading to temporary changes in the perception of color hue and brightness. The importance of reversible changes in the electroretinogram observed in volunteers after sildenafil 100 mg, ascribed to inhibition of phosphodiesterase type 5 in the retina, is unclear (20-22). 

Sildenafil causes increased sensitivity to light, blurred vision, or loss of blue-green color discrimination in 3% to 10% of patients. This results from the agent s inhibition of phosphodiesterase type 6 in the photoreceptor cells in the retina, particularly at doses larger than... 

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