Retigabine anticonvulsant

Retigabine is a novel anticonvulsant drug in development (Phase II). It activates voltage-gated potassium channels and also affects GABA neurotransmission in the GABAyi receptor. ... [Pg.305]

Retigabine which is in phase II clinical trials for epilepsy, is a derivative of the analgesic flupirtine which also has anticonvulsant activity. The anticonvulsant action of retigabine is greater than that of flupirtine, however retigabine is not effective in models of acute pain. [Pg.344]

De Sarro, G., Di Paola, E. D., Conte, G., Pasculli, M. P., De Sarro, A. Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice, Naunyn-Schmiedeberg s Archiv of Pharmacology 2001, 363, 330-336. [Pg.347]

Rostock, A., Rundfeldt, C., Bartsch, R. Effects of the anticonvulsant retigabine in neuropathic pain models in rats Poster presentation, 41st Annual Meeting of the German Society of Pharmacology and Toxicology 2000... [Pg.349]

Rundfeldt, C. and Netzer, R. The novel anticonvulsant retigabine activates M-current in Chinese hamster ovary-cells transfected with human KCNQ2/3 subunits, Neuroscience Letters 2000, 282, 73-76. [Pg.349]

Blackburn-Munro G, Jensen BS (2003) The anticonvulsant retigabine attenuates nociceptive behaviours in rat models of persistent and neuropathic pain. Eur J Pharmacol 460 109-116... [Pg.49]

Main MJ, Cryan JE, Dupere JR et al. (2000) Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine. Mol Pharmacol 58(2) 253-262... [Pg.52]

Rundgeldt C (1999) Characterization of the K+ channel opening effect of the anticonvulsant retigabine in PC12 cells. Epilepsy Res 35 99-107... [Pg.53]

Schenzer A, Friedrich T, Pusch M et al. (2005) Molecular determinants of KCNQ (Kv7) K+ channel sensitivity to the anticonvulsant retigabine. J Neurosci 25(20) 5051-5060... [Pg.53]

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