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RET proto-oncogene

Several inherited cancer syndromes are also known to result from mutations in proto-oncogenes. An example is given by the RET proto-oncogene. Depending on the type of mutation and on which part of the gene is affected, RET mutations can lead to multiple endocrine neoplasia 2A or 2B or familial medullary thyroid carcinoma. These familial cancers are inherited in autosomal dominant fashion. A second example is the CDK4 proto-oncogene, which when mutated can cause familial melanoma. [Pg.340]

C. Eng. The RET proto-oncogene in multiple endocrine neoplasia type 2 and Hirschsprung s disease. Seminars in medicine of the Beth Israel Hospital, Boston. NEn J Med, 335 (13), 943-951, 1996. [Pg.301]

Also T. Attie, A. Pelet, P. Edery, C. Eng, L. M. Mulligan, J. Amiel, et al. Diversity of RET proto-oncogene mutations in familial and sporadic Hirschsprung disease. Hum Mol Genet, 4 (8), 1381-1386, 1995. [Pg.301]

Multiple endocrine neoplasia type 2 RET proto-oncogene... [Pg.403]

Dang GT, Gote GJ, Schultz PN, et al. A codon 891 exon 15 RET proto-oncogene mutation in familial medullary thyroid carcinoma a detection strategy. Mol Cell Probes. 1999 13 77-79. [Pg.56]

Kambouris M, Jackson CE, Eeldman GL. Diagnosis of multiple endocrine neoplasia [MEN] 2A, 2B and familial medullary thyroid cancer [FMTG] by multiplex PCR and heteroduplex analyses of RET proto-oncogene mutations. Hum Mutat. 1996 8 64-70. [Pg.56]

Grieco M, Santoro M, Berlingieri MT, et al. PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas. Cell. 1990 60 557-563. [Pg.333]

Eng C. RET proto-oncogene in the development of human cancer. / Clin Oncol. 1999 17 380-393. [Pg.334]

Beginnings identiHcation of the RET proto-oncogene 2. GDNF a ligand for RET... [Pg.192]

Iwamoto, T. Taniguchi, M. Asai, N. Ohkusu, K. Nakashima, I. Takaha-shi, M. cDNA cloning of mouse ret proto-oncogene and its sequence similarity to the cadherin superfamily. Oncogene, 8, 1087-1091 (1993)... [Pg.599]

The RET proto-oncogene located on chromosome 10 codes for a transmembrane tyrosine kinase. Mutations at codon 634 are directly associated with multiple endocrine neoplasia type 2A and medullary thyroid carcinoma. If children are diagnosed to carry such a mutation, cancer can be prevented by removal of the thyroid gland. Accuracy and reliability of the diagnostic assay is critical here as in... [Pg.41]

Pachnis V, Mankoo B, Costantini F. 1993. Expression of the c-ret proto-oncogene during mouse embryogenesis. Development 119(4) 1005-1017. [Pg.382]

See other pages where RET proto-oncogene is mentioned: [Pg.128]    [Pg.55]    [Pg.17]    [Pg.22]    [Pg.301]    [Pg.301]    [Pg.1927]    [Pg.178]    [Pg.886]    [Pg.309]    [Pg.319]    [Pg.237]    [Pg.237]    [Pg.494]    [Pg.700]    [Pg.279]   
See also in sourсe #XX -- [ Pg.767 , Pg.886 ]

See also in sourсe #XX -- [ Pg.41 ]



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Oncogenes

Oncogenic

Oncogens

Proto-oncogenes

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