Responsive Polymers for DNA Delivery

The concept of using responsive polymer phase transitions to switch binding interactions with DNA was first explored by Hennink and co-workers, who showed that a cationic polymer of N,N (2-dimethylamino)-ethyhnethacrylate (DMAEMA) and related copolymers were able to bind and transfect DNA effectively. Copolymerisation of DMAEMA with NIP Am yielded polymers that complexed with DNA at room temperatore but did not exhibit variations of binding with polymer LCST response. This group observed that low 

More recently, a number of groups have reported modulation of DNA binding and control of gene expression by responsive polymers, [142-151] and although the specific mechanisms and experimental conditions are somewhat varied, nevertheless, the principles of smart synthetic gene delivery vectors have now been established. 

5 Recent Highlights of Actuated Polymers for Drug Delivery Applications 

Wadhwa et al. prepared coatings from the conducting polymer poly (pyrrole) (PPy) that were designed to release an anti-inflammatory drug upon the action of an electrical 

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