Response maximum

May administer a second dose of 5-10 mg 15-30 min after the initial dose if inadequate response. Maximum total dose is 20 mg... 

Oxybutynin IR is best tolerated when the dose is gradually escalated from less than or equal to 2.5 mg twice daily to 2.5 mg three times daily after 1 month. Oxybutynin IR can be further increased in 2.5-mg/day increments every 1 to 2 months until the desired response, maximum recommended dose of 5 mg three times daily, or maximum tolerated dose is attained. 

Flexural member design requires the determination of (1) the design blast loads, (2) the initial design cross-section, (3) an idealized resistance deflection function, (4) the calculated response (maximum deflection) and, (5) allowable ultimate deflection and (6) design for shear. 

It seems evident that detection potential is chosen beyond E2 maximum response, maximum response stability (independent of minor potential fluctuations due to change of temperature, reference potential or working electrode surface). 

B) Evaluating N from the time at which the tracer response maximum occurs From Table 6, the maximum f(t) is at a time between 1 and 3 min. If the data are... 

Respiratory depression IVInjection Initially, 0.5-1 mg/kg. May repeat at 5-min intervals in patients who demonstrate initial response. Maximum 2 mg/kg. IV Infusion Initially 5 mg/min until adequate response or adverse effects are seen. Decrease to 1 -3 mg/min. Maximum 4 mg/kg. 

Diabetes mellitus PO Initially, 1-2 mg once a day, with breakfast or first main meal. Maintenance 1-4 mg once a day. After dose of 2 mg is reached, dosage should be increased in increments of up to 2 mg q 1 -2wk, based on blood glucose response. Maximum 8 mg/day. 

Acute iron intoxication Initially 1 g IM followed by 500 mg every four hours for two doses. Subsequent doses of 500 mg are given 4 to 12 hourly depending on response, maximum 6 g in 24 hours. 

In this way the basic experiment is defined for the linear model, and the gradient that indicates the direction of the fastest response increase or decrease is obtained. When a response maximum or minimum is searched for, the experimental center is moved that way and a new experiment for the linear model performed. The procedure is repeated until moving along the gradient has an effect. When this has no effect, it means we are close to the optimum. Polynomials of higher order, mostly the second, are used in the optimum region. 

In general, a review of the available literature for arili-TN F-a biologies reflects that, at steady state, the highest proportion of the observed response (maximum therapeutic effect) appears to occur in patients with steady-state semm concentrations ranging between 1 to 10 pg/mL, independent of the compound. This is anticipated since the reported affinities of the anti-TN l -a biologies to TNF-a are comparable (etanercept, 65 pM adalimumab, 78 pM and infliximab, 100 pM). Comparable steady-state serum trough concentrations of the drugs are therefore necessary for a >90% suppression of serum TNF-a. 

The three basic types are photoconductive, photovoltaic, and photo-emissive, and all are sensitive to both heat and light. The resistance of a photoconductive cell is lowered when it is illuminated and, over a small range, its response is linear. Cells containing lead sulfide, which is sensitive at wavelengths greater than 700 nm, and cadmium sulfide or selenide, with a sharp response maximum at 710 nm, have been used but may not give a stable response and are largely restricted to specialized applications in other fields. Silicon photodiodes and transistors are sensitive from 340 to 1200 nm with a peak at 900 nm. 

Finally, improvements in the read channel such as the use of partial-response-maximum-Ukelihood (PRML) will enable marks in high-density recording to be detected in the presence of noise. 

The most attractive ratio of (Z,Z)- and (Z, )-7,ll-hexadecadienyl acetate (529 a and 529 b Scheme 91) for the pink boll worm, Pectinophora gossypiella, was claimed to be 1 1 (79, 233). Rothschild 286) found that three species, P. gossypiella, P. endema and P. scutigem, were maximally attracted to ratios of 1 1, 1 0.5 and 1 0.1 Z,Z, to Z,E and indicated that these ratios may provide a mechanism for reproductive isolation. Flint et al. 287) have recently shown that the most attractive ZZ to ZE ratio for the pink boll worm varies with the time of year. In the early season a 2 1 ratio was considerably more attractive than a 1 1 ratio, and, as the season progressed, the response maximum was obtained with a much wider range of ratios. Various ratios of ZZ to ZE isomers have been claimed to be most effective 287). 

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