Response coefficient, metabolic control analysis

Metabolic control analysis (MCA) is a specialized theory that is concerned with particular sensitivity coefficients, elasticity coefficients and control coefficients. These coefficients tell us how a steady state of a biochemical system shifts in response to perturbation in enzyme activities or external (clamped) substrate concentration [53, 209],... [Pg.156]

The metabolic control analysis determines quantitatively the effects of various metabolic pathway reactions on flows and on metabolic concentrations. The analysis defines two coefficients (i) the control coefficients, which characterize the response of the system flows, concentrations, and other variables after parameter perturbations and (ii) the elasticity coefficients, which quantify the changes of reaction rates after perturbations of substrate concentrations or kinetic parameters under specified conditions. [Pg.558]