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Respiratory system, safety

TABLE 19.2. Respiratory System Safety Pharmacology Evaluation... [Pg.740]

Biopharmaceuticals Cardiovascular system Central nervous system International Conference on Harmonization Respiratory system Safety pharmacology... [Pg.386]

Health and Safety Factors. Ttimesic acid is an irritant to the skin, eyes, and respiratory system (140). It is mildly toxic when iagested. The oral LD q ia tats has been reported as 8.4 g/kg (141). Ttimesic acid is flammable, and precautions similar to those noted for tetephthaUc acid and isophthahc acid as regards dust clouds and fire extinguishing agents should be followed. [Pg.499]

Health Hazards Information - Recommended Personal Protective Equipment Self-contained breathing apparatus complete protective clothing safety glasses face shield Symptoms Following Exposure Inhalation causes severe irritation of upper respiratory system. Contact with liquid or vapor causes severe bums of eyes and can cause ulcers and blindness. Contact with skin causes severe burns. Ingestion causes severe burns of mucous membranes General Treatment for Exposure Get immediate... [Pg.53]

Safety pharmacology studies may also be conducted in conjunction with the toxicity studies. These focus on identifying secondary pharmaceutical side effects that may occur, when the drug is administered in the therapeutic range. Emphasis is placed on identifying effects on vital systems, particularly the central nervous, cardiovascular and respiratory systems. [Pg.66]

Murphy, D.J. (1994). Safety pharmacology of the respiratory system Techniques and study design. Drug Dev. Res. 32 237-246. [Pg.762]

Safety pharmacology - indication of adverse pharmacologically mediated actions on central nervous, cardiovascular and respiratory systems... [Pg.116]

Finally the effect of the compound on several body functions is investigated in so-called safety pharmacology studies. The most relevant are the possible effects on the respiratory system, the cardiovascular system and on the central nervous system. Usually these studies are done in rodents, dogs or primates. Lately there has been increased interest in the effect of new drugs on ECG parameters. [Pg.114]

The pharmacological properties of etomidate (Amidate) are similar to those of the barbiturates, although its use may provide a greater margin of safety because of its limited effects on the cardiovascular and respiratory systems. Since it has a relatively short elimination half-life (ti/23 = 2.9 hours), in addition to its use as an induc-... [Pg.296]

CAUTION Hydrofluoric acid (HF) is highly toxic and corrosive, and severely irritating to the respiratory system and eyes All operations should be performed in a well-ventilated fume hood using appropriate safety precautions and procedures. [Pg.145]

Fuel Oil/Bunker C CAS number Flash point IBP Safety profile 68553-00-4 180°F (82.2°C) 400°F (204°C) Vapors can cause respiratory system irritation and dizziness. Direct contact can be severely irritating to eyes and skin. [Pg.249]

Bupropion falls between TCAs and SSRIs in terms of safety in overdose. Death is a rare possibility with an overdose of bupropion alone because there are no adverse effects on the cardiovascular or the respiratory systems (461). Seizures may occur but are readily treatable in a hospital setting. [Pg.151]

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Respiratory system

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