Respiratory system lungs

Uses Pirimicarb is a colorless solid material. It is a selective systemic insecticide with contact effects on stomach (poison) and respiratory system (lungs). It is extensively used for the control of pests that infect a variety of crops (e.g., ornamentals, oilseeds, vegetables, cereals, greenhouse crops). Formulations include... 

Toxicology LD50 (IP, mouse) 13 mg/kg, (IV, mouse) 18 mg/kg poison by IV and IP routes severe lachrymator corrosive possible sensitizer very serious and persistent respiratory system/lung damage may occur... 

Classification Isocyanic acid ester Empirical C7H3CI2NO Properties Wh. to yel. cryst. solid probably irritating odor insol. in water m.w.188.01 m.p. 42-44 C b.p. 101 C (5 mm) flash pt. 77 C Toxicology Highly toxic very serious/persistent respiratory system/lung damage may occur resulting in death may cause breathlessness,... 

Jackson AC, Watson JW, Kotlikoff MI (1984) Respiratory system, lung, and chest wall impedances in anesthetized dogs. J Appl Physiol 57(l) 34—39 Jacky JP (1980) Barometric measurement of tidal volume effects of pattern and nasal temperature. J Appl Physiol 49(2) 319-325... 

Mild exposure to HF via inhalation can irritate the nose, throat, and respiratory system. The onset of symptoms may be delayed for several hours. Severe exposure via inhalation can cause nose and throat bums, lung inflammation, and pulmonary edema, and can also result in other systemic effects including hypocalcemia (depletion of body calcium levels), which if not promptly treated can be fatal. Permissible air concentrations are (42) OSHA PEL, 3 ppm (2.0 mg/m ) as E OSHA STEL, 6 ppm (5.2 mg/m ) as E and ACGIH TLV, 3 ppm (2.6 mg/m ) as E. Ingestion can cause severe mouth, throat, and stomach bums, and maybe fatal. Hypocalcemia is possible even if exposure consists of small amounts or dilute solutions of HE. 

Much of the concern about particulate matter in the atmosphere arises because particles of certain size ranges can be inhaled and retained by the human respiratory system. There is also concern because particulate matter in the atmosphere absorbs and scatters incoming solar radiation. For a detailed discussion of the human respiratory system and the defenses it provides against exposure of the lungs to particulate matter, see Chapter 7. 

Air pollution principally affects the respiratory, circulatory, and olfactory systems. The respiratory system is the principal route of entry for air pollutants, some of which may alter the function of the lungs. 

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