Respiratory disturbance index

RDP respiratory disturbance index treatment of restless legs syndrome and periodic limb move-... 

Respiratory disturbance index A summary measure that quantifies the number of apneas, hypopneas, and respiratory effort-related arousals per hour of sleep. 

While correlation may not be the optimal measure of the usefulness of the Epworth scale for discrimination or prediction (32), there also appears to be no categorical association between ESS score and sleep latency (30,33,34). Thus, although the ESS may be predictive of other variables such as general health status (16) or respiratory disturbance index (12), most of the evidence suggests that its association with sleep latency is tenuous. Similar results emerge from studies comparing ESS with the other (newer) objective measure of EDS, the maintenance of wakefulness test (MWT). In a large narcolepsy sample, the correlation between ESS and MWT was weak (r = -0.29, p <. 001) (35). 

The lack of association, or weak correlation, between subjective scales and objective measures suggests that subjective and objective measures evaluate different aspects of sleepiness. This is the prevailing view (15,30,31,35,36), and it is supported by the association between the ESS, nocturnal sleep latency (on polysomnogram), and respiratory disturbance index (12). 

Although the incidence of SDB has not been systematically examined in neuromuscular disorders (NMD), many case series have been published in different diseases (58-62). According to Labanowski et al. (58), significant SDB with a respiratory disturbance index >15/hr, occurs in up to 42% of patients with NMD, from 16.7% in early stages of ALS (59) to 57% in Duchenne muscular dystrophy (DMD) (60). The severity, duration, and distribution of muscle weakness in NMDs influence the prevalence of SDB. Ragette et al. (63) noted progression of SDB from rapid eye movement (REM) elated hypopneas to REM-related mixed hypopneas and hypoventilation, followed by both REM and non-REM hypoventilation through to diurnal respiratory failure. 

Properties Solid m.w. 733.05 dens. 0.920-0.935 m.p. 44-47 C ref. index 1.4560-1.4590 flash pt. (PMCC) 185 C Toxicology May be harmful by inh., ing., or skin absorption may cause skin/eye/mucous membrane/upper respiratory tract irritation ing. can cause Gl disturbances TSCA listed... 

Properties Colorless clear liq., benzene odor sol. in alcohol, benzene, ether, acetone, chloroform, petrol, ether, ethyl acetate misc. with most org. soivs. very si. sol. in water m.w. 92.13 dens. 0.866 (20/4 C) vapor pressure 36.7 mm Hg (30 C) m.p. -94.5 C b.p. 110.7 C flash pt. (CC) 4.4 C ref. index 1.4967 (20 C) KB value 105 Toxicology ACGIH TLV/TWA 100 ppm STEL 150 ppm LD50 (oral, rat) 7.53 g/kg, (skin, rabbit) 12,124 mg/kg toxic by ing., inh., IP, and skin absorption irritant to eyes, skin, respiratory tract severe dermatitis on direct contact ing. may cause lung aspiration overexposure by inh. may cause CNS excitation/depression high cones, may cause paresthesia, vision disturbances, dizziness, nausea, headache, narcosis, death experimental teratogen. 

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