Respiratory asthma, paracetamol

Parvolex ) is used a MUCOLYTIC agent, which reduces the viscosity of sputum, so can be used as an expectorant in patients with disorders of the upper respiratory airways, such as chronic asthma and bronchitis. It is also used orally to treat abdominal complications associated with cystic fibrosis, and locally in the eye to increase lacrimation and mucus secretion. It is also used intravenously as an antidote in paracetamol poisoning. 

The effect of reduction in antioxidant activity has been explored in another way, by exposure to paracetamol, which depletes the antioxidant glutathione. In adults in Britain there was a positive relationship between paracetamol use and asthma [89(111)]. Paracetamol sales per capita have been examined in relationship to ISAAC data in 36 countries, and European Community Respiratory Health Survey data in 18 countries. There were positive correlations between paracetamol sales and symptoms of wheeze, rhinoconjunctivitis and eczema. An increase in paracetamol sales of lOg/capita was associated with an increase of 5.2% in asthma symptoms in 13- to 14-year-olds and 2.6% in adults [90(111)1. 

Respiratory More evidence has been published on the topic of paracetamol use and asthma. In a prospective birth cohort study of 620 children with a first-degree family history of allergic disease, who were followed until age 7 years, the use of paracetamol was associated (with borderhne significance) with a risk of childhood asthma, but the association became clearly non-significant after adjustment for the frequency of respiratory infections [17 ]. There was no association between the use of paracetamol for non-respiratory causes and asthma. 

Respiratory More evidence has been published about the possible association between paracetamol and asthma. In a multicenter case-control study of 521 patients with asthma and 507 controls, weekly use of paracetamol, compared with less frequent use, was associated with asthma [25 ]. A study of 19 349 adult twins ermoUed in the nationwide Danish Twin Registry showed a higher prevalence of asthma in subjects with frequent intake of paracetamol (OR = 2.16 95% C3 = 1.03, 4.53) after adjusting for confounders [26 "]. Furthermore, a study of 205 487 children aged 6-7 years showed that paracetamol use for fever in the first year of life was associated with a higher risk of asthma... 

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