Resources for Combinatorial Chemistry

Bcck-Sieklinger, A., and Weber, P. Combinaloriul Strategics in Biology and Chemistry. New York, John Wiley Sons. 2002. (The finest short intix uction available) 

The Combinatorial Index. New York. Academic Pre.ss. 1998 (a comprehensive, chemistiy-orienlcd reference). 

Czamik. A. W.. and DeWiti, S. H. (eds.) A Practical Guide to Combinatorial Chemistry. Washington, DC. American Chemical Socicly. 1997. 

Fenniri. H.. Combinatorial Chemistry—A Practical Approach. Oxford, UK, Oxford University Press. 2000. (Laboratory experiments) 

and Viswanadhan. V. N. Combinatorial Library Design and Evaluation. Principles, Software Tools, and Applications in Drug Discovery. New York, Marcel Dekkcr, 2CI0I. 

---

Appendix Chem informatics and Web Resources for Combinatorial Chemistry... 

This review covers recent literature, and literature going back to the 1960s. It is intended as a resource for the chemist when planning a solid-phase synthesis. Through the references given, the chemist can gain an appreciation as to how a reaction may be performed on the solid phase. The conditions previously described may not be ideal for combinatorial chemistry. However, they may provide the chemist with a useful starting point. 

Die Natur der Chemie, FUTURE (Hoechst Magazin), August 1996 Vision of large-scale production in shoebox-sized plants nature and plant ceUs as model for micro reactors sustainable development central role of catalysis general advantages of micro flow use of clean raw materials minimization of waste the next step in the sequence acetylene-to-efhylene chemistry ethane chemistry renewable resources combinatorial chemistry intelligent and creative solutions [229]. 

Combinatorial chemistry has provided new ways for the pharmaceutical industry and for academic researchers to address specific problems in a time- and resource-efficient manner. Given the involvement of specific oligosaccharide structures in signal transduction processes, combinatorial carbohydrate libraries are... 

Combinatorial Mixture Screening The increased popularity of LC/MS-based methods combined with limited resources resulted in advances that effectively matched combinatorial chemistry samples (i.e., complexity) with instrument time. Richmond, Yates, and coworkers (Richmond et al, 1999 Yates et al.,2001) demonstrated the use of flow injection analysis (FIA)-LC/MS systems for rapid purity assessment and combinatorial mixture screening, respectively. These LC/MS-based applications addressed two critical bottlenecks HPLC... 

---