Resin for SPOS

There is a large range of resins available for SPOS. These resins are derivatised polymer supports with a range of linkers. The roles of linkers are (i) to provide point(s) of attachment for the tethered molecule, akin to a solid supported protecting group(s), (ii) to provide distance from the polymeric backbone in order to minimise interactions with the backbone, (iii) to enable cleavage of product molecules under conditions compatible with the stability of the molecules and the reaction conditions employed for chemical transformations. Hence in order to 

The major impetus for the development of solid phase synthesis centers around applications in combinatorial chemistry. The notion that new drug leads and catalysts can be discovered in a high throughput fashion has been demonstrated many times over as is evidenced from the number of publications that have arisen (see references at the end of this chapter). A number of approaches to combinatorial chemistry exist. These include the split-mix method, serial techniques and parallel methods to generate libraries of compounds. The advances in combinatorial chemistry are also accompani by sophisticated methods in deconvolution and identification of compounds from libraries. In a number of cases, innovative hardware and software has been developed for these purposes. 

Ready to use CombiKits which contain a variety of pre-weighed building blocks are available from Aldrich Chemical Company. 

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