Repertoire, molecular

Lancet D, Sadovsky E and Seidemann E 1993 Probability model for molecular recognition in biological receptor repertoires significance to the olfactory system Proc. Natl Acad. Sci. USA 90 3715-19... 

In summary, a DNA-supported asymmetric interface located within the DNA-binding domains of these nuclear receptors provides the molecular basis for receptor heterodimers to distinguish between closely related response elements. RXR can provide a repertoire of different dimerization surfaces, each one unique for a specific partner, allowing dimers to form that are adapted to the length of the spacer region in their corresponding response elements. 

The classical PTPs can be subdivided into receptorlike PTPs and nonreceptor, cytosolic PTPs. The second category of PTPs are broadly defined as dual specificity phosphatases (DSPs), which dephosphorylate pSer/ pThr as well as pTyr. MAP kinase phosphatases (MKPs) ( MAP kinase cascades) and PTEN are examples of DSP family members. Remarkably, PTEN also has lipid phosphatase activity that is specific for phosphatidylinositol-3,4,5-trisphosphate generated in response to the actions of PI3K. Finally, the class of low molecular mass (LM-) PTPs and that of CDC25 PTPs accomplish the cells repertoire of PTPs (Fig. 3). 

The use of molecular biology methods, described in Section 5.3 seems to be especially worthwhile as it offers novel possibilities of optimization on process adjustment. Directed evolution leads to the formation of new biocatalysts with improved characteristics (selectivity, activity, stability, etc.). Incorporation ofnon-proteinogenic amino acids makes it possible to reach beyond the repertoire of building blocks used by nature. The prospect of bioconjugate preparation offers the possibility to form functional clusters of enzymes and to perform multiple synthetic steps in one pot. 

There are two major experimental techniques that can be used to analyze hydrogen bonding in noncrystalline polymer systems. The first is based on thermodynamic measurements which can be related to molecular properties by using statistical mechanics. The second, and much more powerful, way to elucidate the presence and nature of hydrogen bonds in amorphous polymers is by using spectroscopy (Coleman et al., 1991). From the present repertoire of spectroscopic techniques which includes IR, Raman, electronic absorption, fluorescence, and magnetic resonance spectroscopy, the IR is by far the most sensitive to the presence of hydrogen bonds (Coleman et al., 1991). 

In conclusion, these results demonstrate that affinity and specificity of A2.1-restricted TCRs, selected in Tg mice by circumventing self-tolerance to universal hdm2- and wt p53-derived CTL epitopes, can be successfully delivered into human T lymphocytes. This, however, is precisely the molecular requirement to rescue the human T cell repertoire with high-affinity leukemia and tumor-reactive TCRs that have been lost due to the establishment of antigen-specific self-tolerance [13, 14]. 

From a chemical point of view, the half-life of fluorine-18 allows multi-step synthetic approaches that can be extended over hours. Fluorine-18 has therefore, in spite of its somewhat limited chemical repertoire, been effectively used for the labelling of numerous both relatively simple and complex bioactive chemical structures [3,5-9], including high-molecular-weight macromolecules such as peptides, proteins [10-13] and oligonucleotides [14-18]. General considerations on radiochemistry involving short-lived positron emitters will be discussed in Section 2.3. 

With this repertoire of bonding possibilities at our disposal, we car construct the molecular structures of various boron-hydrogen compounds, both neutral species and anions. The simplest is the tetrahydroborate126 or borohydride ion, BH. Although borane is unstable with respect to dimerization, the addition of a Lewis base, H , satisfies the fourth valency of boron and provides a stable entity. Other Lewis bases can coordinate as well. 

Foster, S.J., Brezinschek, H.-P., Brezinschek, R.I., Lipsky, RE. (1997). Molecular mechanisms and selective influences that shape the kappa gene repertoire of IgM+ B cells. J. Clin. Invest. 99, 1614-1627. 

A more sophisticated way to look at charge distribution is the molecular electrostatic potential energy map of the reactant(s). Programs like SPARTAN can compute and display the MEP of a molecule as part of its quantum mechanical repertoire. In an alternate visualization of the MEP, it is common for such graphics programs to display the electron... 

In the past decade, an impressive repertoire of methods has been developed to permit drug development against soluble targets at the molecular level. In addition to fragment screening methods, structural biology has played a key role in this process. Although at present no... 

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