REPAIR AND REGENERATION REBUILDING, IN ADDITION TO PRESERVING, THE DAMAGED MYOCARDIUM

REPAIR AND REGENERATION REBUILDING, IN ADDITION TO PRESERVING, THE DAMAGED MYOCARDIUM 

Following an acute myocardial infarction and irreversible tissue damage lost tissue is replaced mostly by scar viable myocytes become hypertrophic as part of a compensa- 

Reference Design Delivery Dose (pg/kg) Size (n) Primary Endpoints Results 

Sellke et al.84 Ph I, open label (pilot study) HA beads 0, 1, 10 pg 8 Mortality, toxicity, angina, stress perfusion scans Safety and technical feasibility demonstrated 

Laham et al.85 Ruel et al.85 89 Ph I/II, R, DB, PC HA beads 0, 10, 100 pg 24 CCS, SPECT Safety and technical feasibility demonstrated in short and long term 

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