Renal physiology definition

Nowadays, this definition can be considered as classical. Because all of these criteria are rarely met simultaneously, the concept of uremic toxins has changed. In the new concept, substances that damage normal physiological functions, or interfere with physiological defense mechanisms in renal failure, have also been recognized as uremic toxins. Some may play a role in the progression of renal disease, inducing uremic symptoms, and may contribute to dialysis-related complications. 

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