Renal physiology and

Knowledge of renal physiology, and to some extent of its modification by diuretics, has advanced considerably since the subject was reviewed in a previous contribution to this series [286]. Other work quoted [287] at that time strongly suggested that thiazides and diuretics of similar effectiveness exerted their primary... 

PURPOSE AND RATIONALE Dogs have been extensively used to study renal physiology and the action of diuretics. Renal physiology of the dog is claimed to be closer to man than that of rats. Oral absorbability of diuretic substances can appropriately be studied in dogs. Using catheters, interval collections of urine can be made with more reliability than in rats. Simultaneously, blood samples can be withdrawn to study pharmacokinetics. 

Lindeman RD. Overview Renal physiology and pathophysiology of aging. Am J Kidney Dis 1990 26 275-82. 

Further details on renal physiology and water regulation appear in the Sodium, Potassium, Chloride, and Water section. 

Fig. 5.3) (274). The multiple activities of these substances were the topic of intense research in the 1960s and 1970s, where roles in reproductive, cardiovascular, pulmonary and renal physiology, and pathophysiology (pain, inflammation, cancer) -were identified. The discovery of thromboxane (275) and prostacyclin (276) came later and expanded the role of the eicosanoids as powerful substances in human physiology. 

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