Renal failure parathyroid hormone, role

Michaud J, Naud J, Chouinard J, Desy F, Leblond FA, Desbiens K et al. Role of parathyroid hormone in the downregulation of liver cytochrome P450 in chronic renal failure. J Am Soc Nephrol 2006 17 3041-8. 

Schaefer L, Malchow M, Schaefer RM et al. (1996) Effects of parathyroid hormone on renal tubular proteinases. Miner Electrolyte Metabol 22 182-186 Shimizu T, Hata S, Kuroda T et al. (1999) Different roles of two types of endothelin receptors in partial ablation-induced chronic renal failure in rats. Eur J Pharmacol 381 39-49 Stockelman MG, Lorenz JN, Smith FN et al. (1998) Chronic renal failure in a mouse model of human adenine phos-phoribosyltransferase deficiency. Am J Physiol 275 Renal Physiol 44 F154-F163... 

Yi H, Fukagawa M, Yamamoto H et al. (1995) Prevention of enhanced parathyroid hormone secretion, synthesis and hyperplasia by mild dietary phosphorus restriction in early chronic renal failure in rats. Possible direct role of phosphorus. Nephron 70 242-248... 

In the kidneys, parathyroid hormone increases 1 -hydroxylation of calcidiol and reduces 24-hydroxylation. This is not the result of de novo enzyme synthesis, but an effect on the activity of the preformed enzymes, mediated by cAMP-dependent protein kinases. In turn, calcitriol has a direct role in the control of parathyroid hormone, acting to repress expression of the gene. In chronic renal failure, there is reduced synthesis of calcitriol, leading to the development of secondary hyperparathyroidism that results in excess mobilization of bone mineral, hypercalcemia, hypercalciuria, hyperphosphaturia, and the development of calcium phosphate renal stones. 

Goyal S, Huhn KM, Provost TT. Calciphylaxis in a patient without renal failure or elevated parathyroid hormone possible aetiological role of chemotherapy. Br J Dermatol 2000 143(5) 1087-90. 

Akmal M, Goldstein DA, Multani S Massry SG. (1984). Role of uremia, brain calcium and parathyroid hormone on changes in electroencephalogram in chronic renal failure. Am J Physiol 246 (Renal, Fluid, Electrolyte Physiol. 15), F575-F579. 

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