Renal failure glycerol-induced 46

Chander V, Chopra K. 2006. Protective effect of resveratrol, a polyphenolic phytoalexin on glycerol-induced acute renal failure in rat kidney. Renal Failure 28 161-169. 

We are able to identify the presence of this disorder, and summarize the diagnosis and treatment because (a) we had personal contact with the patients, (b) we had previous knowledge of the hemodynamics of acute renal failure, (c) we had been carrying out animal experiments into glycerol-induced acute renal failure (myohemoglobin-uric acute renal failure) for many years, and (d) a new diagnostic procedure, a computed tomography (CT) scan, had been developed and could be employed. 

Shah SV and Walker PD. Evidence suggesting a role for hydroxyl radical in glycerol-induced acute renal failure. Am J Physiol Renal Physiol 255 F438-443,1988. 

Bidani AK, Churchill PC. Aminophylline ameliorates glycerol-induced acute renal failure in rats. Can J Physiol Pharmacol 1983 61 567-571. 

Hagnevik K, Gordon E, Lins LE, et al. Glycerol-induced haemolysis with haemoglobinuria and acute renal failure. Lancet 1974 i 75-77. 

Roberts PR, Black KW, and Zaloga GP (1997) Enteral feeding improves outcome and protects against glycerol-induced acute renal failure in the rat. American Journal of Respiratory and Critical Care Medicine 156(4 Pt 1) 1265-1269. 

Huang, Z.H. et al. (2000) Expression and fimction of P-glycoprotein in rats with glycerol-induced acute renal failure. European Journal of Pharmacology, 406 (3), 453-460. 

Lin JH, Lin T. Renal handling of drugs in renal failure. I. Differential effects of uranyl nitrate- and glycerol-induced acute renal failure on renal excretion of TEAB and PAH in rats. J Pharmacol Exp Ther 1988 246 896-901. 

Recent experimental studies in rats with acute glycerol-induced renal failure and with chronic renal failure showed a decreased expression of intestinal, renal and brain P-glycoprotein [39-41]. Other authors could not confirm this finding [42]. The clinical relevance of these experimental observations remains unclear. 

Kunihara M, Nagai J, Murakami T, Takano M. Renal excretion of rhodamine 123, a P-glycoprotein substrate, in rats with glycerol-induced acute renal failure. J Pharm Pharmacol 1998 50(10) 1161-1165. 

Subtotal renal ablation Adriamycin nephrosis Glycerol-induced acute renal failure... 

Glycerol-induced acute renal failure Papanicolaou et al 1986 (258)... 

Torres, V.E., Strong, C.G., Romero, J.C. and Wilson, C.M. (1975). Indomethacin enhancement of glycerol-induced acute renal failure in rabbits. Kidney Int., 7, 170-78... 

Benabe, J.E., Klahr, S., HofifiTian, M.K. and Morrison, A.R. (1980). Production of thromboxane by the kidney in glycerol-induced acute renal failure in the rabbit. Prostaglandin, 19, 333-347... 

Sraer, J.D., Moulonquet-Doleris, L., Relarue, F., Sraer, J. and Ardaillou, R. (1981). Prostaglandin synthesis by glomeruli isolated from rats with glycerol-induced acute renal failure. Circ. Res., 49, 775-7S3... 

Papanicolaou, N., Hatziatoniou, C. and Bariety, J. (1986). Selective inhibition of thromboxane synthesis partially protected while inhibition of angiotensin II formation did not protect rats against acute renal failure induced with glycerol. Prostagl. Leak. Med., 1, 29-35... 

Thromboxane is synthesized by the kidney [52] and the production is enhanced in many situations leading to renal failure, i.e. uretereal obstruction (in the rabbit [53], in the rat [54]), renal vein constriction [55] and glycerol induced renal failure [56]. TXAj is the major metabolite of arachidonic acid in human cortical hydronephrotic tissue [57]. 

Renal vein constriction for 1-2 days also markedly increased the biosynthesis of both TXA2 and PGE2 by the kidney [55]. Acute renal failure induced by glycerol in the rabbit also led to a pronounced TXA 2 production by the kidney [56]. 

Izuwa, Y, Kusaba, J., Horiuchi, M., Aiba, T., Kawasaki, H., and Kurosaki, Y. (2009) Comparative study of increased plasma quinidine concentration in rats with glycerol and cisplatin induced acute renal failure. Drug Metab. Pharmacokinet. 24, 451-157. 

Hagnevik, K., Gordon, E., Lins, L. E., Wil-helmsson, S. and Foster, D. (1974) Glycerol induced hemolysis with hemoglobinuria and acute renal failure. Lancet, 1, 75. 

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