Relative Mutagenic Efficiency RME

The fact that the ratio of the slopes of the two linear frequency curves is equal to the ratio of the initial slopes of the yield curves is evident from equation (16) that these are in turn equal to the ratio of the corresponding integrals of Y z) is evident from equation (17) and that all are equal to the ratio of the corresponding values of Fmax is evident from equation (18). Thus, accurate measurements of Fmax can be used to determine RMEs under the conditions stated in the preceding definition. 

The equalities given by expression (48) also hold for other kinetic patterns such as LkyQm), although in this case RME cannot be defined in terms of the slope of the yield curve at the origin because for Qrn this slope is zero. However, as is evident from equations (47) and (18), h for (LkyQm) differs from Iz Lk,Lm) only in a constant of proportionality. In fact, for any given pure power law kinetic pattern qkypm), RME can be defined consistently in terms of the ratios of Iz as measured by the ratios of K ax [cf. equation (38)]. 

If mutagens A and B follow the same monophasic kinetic patterns in a 

For more complex cases involving biphasic kinetic patterns, it is very cumbersome to obtain explicit representations for RME in terms of Fmax ratios. In such cases, it would probably be best to obtain the appropriate values of z and Iz by numerical analysis of the yield data. 

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