Relapse problems

Since the majority of AML patients lack a HLA-identical donor, investigators began to consider the use of the patient s own bone marrow, obtained while in CR, as a source of hematopoietic regeneration. However, relapse continues to be a problem... 

Now there are a number of problems with relapse-prevention studies. One is the fact that many people who are taken off antidepressants experience withdrawal symptoms, which in severe cases can last for months. Some of these withdrawal symptoms - sadness, suicidal thoughts, crying spells, trouble concentrating, irritability, anxiety, agitation and insomnia, for example - are also symptoms of depression.12 These withdrawal symptoms could lead both patients and researchers to think that the patient has relapsed. 

A second problem with relapse-prevention trials is related to research suggesting that the use of antidepressants might make people more vulnerable to relapse. Patients who are being treated... 

Signs and Symptoms Flu-like symptoms with fever, headache, drowsiness, cough, abdominal pain, nausea, vomiting, weakness, problems with swallowing, and blurred vision that may progress to encephalitis with drowsiness, disorientation, severe hypertension, rapid heart rate (tachycardia), very high temperature, convulsions, and coma. Encephalitis may be delayed up to 4 months postexposure. Nipah virus is also known to cause relapse encephalitis. 

Every patient who uses tobacco should be offered at least brief treatment. All patients attempting tobacco cessation should be offered practical counseling (problem-solving/skills training), social support, stress management, and relapse prevention. 

Interventions are more effective when they last greater than 10 minutes, involve contact with a professional, provide at least four to seven sessions, and provide nicotine-replacement therapy (NRT). Group and individual counseling is effective, and interventions are more successful when they include social support and training in problem-solving, stress management, and relapse prevention. 

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