Skin graft rejection

Newt, Notophthalmus viridescens adults, single acute exposure of 20 Gy, one limb shielded or 22 Gy, whole body, no limbs shielded Frog, Rana sp., single acute exposure Forelimb regeneration completely suppressed when limbs to be amputated were irradiated directly. Irradiated limbs had severe and protracted inflammation, with total resorption of the affected limbs in 85% of the cases. Shielded limbs subsequently amputated had delays — but not suppression — in rate of forelimb regeneration and skin graft rejection 4... 

Cohen, N., Chronic skin graft rejection in the Urodela I. A comparative study of first-and-second-set allograft reactions, J. Exp. Zool., 167, 36, 1968. 

Nitrofurazone, a topical antibiotic, is occasionally used in the treatment of burns or skin grafts in which bacterial contamination may cause tissue rejection. 

Of all forms of skin grafting, autografting is by far the most likely to be successful. In other forms of grafting, a patient is likely to suffer not only from infections developing from the loss of skin, hut also from immune responses as his or her body begins to reject the "foreign" implant, the skin from some nonself source. 

The close relationship between the thymus and the more classic endocrine organs is further illustrated by the results of studies designed to elucidate the effects of endocrine ablative surgery on thymus gland function. Prepubertal orchidectomy resulted in an increase in thymus weight and accelerated rejection of skin grafts (Castro, 1974). The effects are reversible by testosterone administration. Adrenalectomy also delayed the involution of the thymus (Dougherty, 1952 Ishidate and Metcalf, 1963). 

Stage 1 membranes are not rejected and therefore appear to be superior to cadaver and porcine skin grafts. In studies of Stage 1 membranes with extensively burned humans, the silicone (top) layer was electively removed between 25 and 46 days after grafting and replaced by autoepidermal grafts. This procedure eventually yielded a relatively scar-free donor site and a largely scar-free treatment site that appeared to require no further manipulation. 

Koga S, Kapoor A, Novick AC, Toma H, Fairchild RL. RANTES is produced by CD8+ T cells during acute rejection of skin grafts. Transplant Proc 2000 32 796-797. 

Kondo, T., Novick, A. C., Toma, H., and Fairchild, R. L. (1996) Induction of chemokine gene expression during allogeneic skin graft rejection. Transplantation 61, 1750-1757. 

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