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Reinforcement mesolimbic dopamine pathway

FIGURE 10-9. The dopamine hypothesis of psychosis. Hyperactivity of dopamine neurons in the mesolimbic dopamine pathway theoretically mediates the positive symptoms of psychosis, such as delusions and hallucinations. This pathway is also involved in pleasure, reward, and reinforcing behavior, and many drugs of abuse interact here. [Pg.376]

The reinforcing actions of nicotine are very similar to those of cocaine and amphetamine, since dopaminergic cells in the mesolimbic dopamine pathway receive direct nicotinic cholinergic input, which is stimulated by cigarette smoking (Figs. [Pg.518]

It is well established that nicotine stimulation of the mesolimbic dopamine (DA) pathway is essential to the reinforcing action of nicotine (Balfour 2004 Corrigall and Coen 1991). Considerable evidence suggests that alterations in this pathway may also be essential to the nicotine abstinence syndrome, particularly to its depression-like dimension. During withdrawal from continuous nicotine infusion, rats displayed reduced activity levels and reduced DA content in the striatum... [Pg.419]

See other pages where Reinforcement mesolimbic dopamine pathway is mentioned: [Pg.503]    [Pg.506]    [Pg.509]    [Pg.443]    [Pg.281]    [Pg.91]    [Pg.211]    [Pg.413]    [Pg.50]    [Pg.41]    [Pg.229]    [Pg.443]    [Pg.73]    [Pg.144]    [Pg.282]    [Pg.28]    [Pg.83]    [Pg.177]    [Pg.379]    [Pg.154]    [Pg.395]    [Pg.350]   
See also in sourсe #XX -- [ Pg.503 , Pg.504 ]



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