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Regulation of fluxes

The approach that is used to identify a regulatory mechanism in any biochemical process is discussed in Chapter 3. In brief, the approach is (i) identify the regulatory enzymes or processes (ii) study the properties of the enzymes or processes (iii) on the basis of the properties, formulate a theory of regulation (iv) test the theory. [Pg.194]

This is now done for the Krebs cycle, electron transfer and ATP generation. Finally, the proposed overall mechanism for regulation of flux from glycogen to CO2 and HjO is described. The increased flux also requires an increased supply of oxygen (Chapter 13) (Box 9.3). [Pg.194]

Citrate synthase, isocitrate dehydrogenase and oxogluta-rate dehydrogenase are key enzymes regulating the flux through the cycle all three catalyse non-equilibrium reactions (Chapter 3). [Pg.194]

On the r of August, 1774,1 endeavoured to extract air from mercurius calcinatus per se and I presently found that, by means of the lens, aif was expelled from it very readily. . . But what surprised me more than I can well express, was, that a candle burned in this air with a remarkably vigorous flame. . .  [Pg.195]

On the S of this month [March, 1775] I procured a mouse, and put it into a glass vessel, containing. . . the air.. . Had it been common air, a full-grown mouse, as this was, would have lived in it about a quarter of an hour. In this air, however, my mouse lived a full half hour and though it was taken out seemingly dead, it appeared to have been only exceedingly chilled for, upon being held to the fire, it presently revived, and appeared not to have received any harm from the experiment. [Pg.195]


Regulation of flux through glycolysis, from glucose to pyruvate and then to acetyl-CoA in muscle... [Pg.108]

The regulation of biochemical processes, described so far, in this book, is primarily the regulation of flux that is, the amount of biochemistry that is achieved in a certain period of time. In contrast, in the cycle, at least other than in the embryo, time is much less important. The important decision that a cell has to take is whether there are sufficient materials and fuels available in the preceding stage to allow the next step to proceed satisfactorily. If not, then the cycle must be arrested to prevent entry into the next phase. The cell, therefore, has to check if all the conditions are satisfactory, so that these positions of regulation are known as checkpoints. There are at least two one is present in the Gj phase, the other in the G2 phase (Figure 20.30). For example, DNA duplication can only proceed if ... [Pg.474]

The theoretical background concerning regulation of fluxes through metabolic pathways, the identification of regulatory points and the mechanisms whereby different catabolic and synthetic pathways are integrated has been expertly covered by Barrett (39). Earlier reviews of the regulation of respiratory metabolism in cestodes are those of Bryant (99, 100). [Pg.85]

Fig. 11-19 Regulation of flux through the Krebs cycle. Details of the chemical structures and a complete list of enzyme names are given in Fig. 10-9. Fig. 11-19 Regulation of flux through the Krebs cycle. Details of the chemical structures and a complete list of enzyme names are given in Fig. 10-9.

See other pages where Regulation of fluxes is mentioned: [Pg.62]    [Pg.64]    [Pg.65]    [Pg.194]    [Pg.195]    [Pg.197]    [Pg.198]    [Pg.199]    [Pg.471]    [Pg.733]    [Pg.44]    [Pg.333]    [Pg.249]    [Pg.254]    [Pg.254]    [Pg.381]    [Pg.24]    [Pg.354]    [Pg.106]    [Pg.36]   


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Flux regulation

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