Regulation of Airway Smooth Muscle

Gerthoffer, W.T. (1991). Regulation of the contractile element of airway smooth muscle. Am. J. Physiol. 261 (Lung Cell Mol. Physiol. 5), L15-L28. 

Asthma is a complex respiratory disorder that involves mast cell degranulation, mucous secretions, and smooth muscle hypertrophy and hyperresponsiveness. Smooth muscle hyperresponsiveness has suggested some defect in the regulation of smooth muscle contractility. Therefore, a number of studies concerning asthma have centered on whether alterations in the regulation of smooth muscle contraction (Figure 4) are responsible for hyperactivity in asthmatic airway smooth muscle. 

Pyne, S. and Pyne, NJ., 1996, The differential regulation of cyclic AMP by sphingomyehn-derived lipids and the modulation of sphingohpid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle. Biochem. J. 315 917-923. 

Shore SA, Moore PE. Regulation of P-adrenergic responses in airway smooth muscle. Resp Physiol Neurobiol 2003 137 179-195. 

F5. Foda, H. D., George, S., Rollo, E., et al.. Regulation of gelatinases in human airway smooth muscle cells Mechanism of progelatinase A activation. Am. J. Physiol. 227, L174-182 (1999). 

Webb, B.J.L., Hirst, S.J. and Giembycz, M.A. (2000). Protein kinase G isoenzymes a review of there structure, regulation and role in regulating airways smooth muscle tone and mitogensis. Br. J. Pharmacol. 130, 1433-1452. 

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