Airway smooth muscle regulation

Asthma is a complex respiratory disorder that involves mast cell degranulation, mucous secretions, and smooth muscle hypertrophy and hyperresponsiveness. Smooth muscle hyperresponsiveness has suggested some defect in the regulation of smooth muscle contractility. Therefore, a number of studies concerning asthma have centered on whether alterations in the regulation of smooth muscle contraction (Figure 4) are responsible for hyperactivity in asthmatic airway smooth muscle. 

Pyne, S. and Pyne, NJ., 1996, The differential regulation of cyclic AMP by sphingomyehn-derived lipids and the modulation of sphingohpid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle. Biochem. J. 315 917-923. 

Pyne, S., Chapman, J., Steele, L. and Pyne, N.J., 1996, Sphingomyehn-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. Ear. J. Biochem. 237 819-826. 

Like the 5-HT1A receptor (see Section 2.1), the 5-HT2A receptor can regulate several transport processes. The 5-HT2A receptor activates the type 1 sodium-proton exchanger (NHE-1) in renal mesangial cells (187,227) and vascular smooth muscle cells (222), the Na+K+-AIPase (sodium pump) in airway smooth muscle cells (228), and the Na+/K+/2Cr cotransporter when 5-HT2A receptor transfected... 

Gerthoffer, W.T. (1991). Regulation of the contractile element of airway smooth muscle. Am. J. Physiol. 261 (Lung Cell Mol. Physiol. 5), L15-L28. 

Shore SA, Moore PE. Regulation of P-adrenergic responses in airway smooth muscle. Resp Physiol Neurobiol 2003 137 179-195. 

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