Regeol regelii

T. wilfordii has been used as a traditional medicine in China for many centuries. The plant has also been used to treat rheumatoid arthritis and spondylitis [92]. It has been reported that there is a strong relationship between the production of interleukin - 1 (IL-1) by the synovium and the degree of inflammation of the arthricular synovial membrane in rheumatoid artritis [93-95]. Regeol A (76), B (3) and C (77) [27], isolated from T. wilfordii var. regelii showed moderate to low inhibitory activity for IL-1 a and IL-lp release from lipopolysaccharide-stimulated human peripheral mononuclear cells compared to prednisolone as a reference compound. 

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