Regenerative medicine extracellular matrix

Daley WP, Peters SB, Larsen M (2008) Extracellular matrix dynamics in development and regenerative medicine. J Cell Sci 121(Pt 3) 255-264... 

When electrospun, the resulting scaffolds mimic the structure of extracellular matrix. Thus, further development of these polymers is needed to meet the demands of the next generation of biomaterials and support the advancement of medical devices, tissue engineering, regenerative medicine, and nanotechnology. 

The use of supramolecular hydrogels in regenerative medicine is inspired by the extracellular matrix (ECM), which provides the natural scaffolding for cells inside the body [14]. Mimicking the ECM is a major objective for tissue engineering, in order to create a regenerating niche for cells [15]. The natural ECM is inherently... 

Skardal A (2014) Extracellular matrix-like hydrogels for applications in regenerative medicine. In Connon CJ, Hamley IW (eds) Hydrogels in cell-based therapies. Royal Society of Chemistry, Cambridge, doi 10.1039/9781782622055-00191... 

Figure 16.1 Strategies of regenerative medicine, including the tissue engineering approach that uses bioresorbable polymers for cell dehvery ECM, extracellular matrix).

This chapter intends to provide an overview of the use of polymer composites applied to tissue engineering and regenerative medicine, focused on bone and cartilage. It will describe the constiments and arrangement of the natural extracellular matrix of bone and cartilage and the structure requirements to attain the demands of functional tissues. It will state evidences that polymer composites are the appropriate answer to substitute and restore damaged native tissues, from the more established solutions to the most advanced (Fig. 5.1). 

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