Reductase pathway

Isoprenoids or terpenoids are a large class of naturally occurring organic compounds with tremendous chemical and structural diversity. They are organic materials produced in the HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA) reductase pathway... 

The glutathione redox system is an essential player in controlling the redox state within the cell, the glutathione/glutathione reductase pathway attempts to keep a stable cellular redox balance... 

The alternative reductase pathway (II in Eq. 17-1) is often faster. It makes use of an additional isomerase which converts 3-trans, 5-czs-dienoyl-CoA into the 2-1vans, 4-trans isomer in which the double bonds are conjugated with the carbonyl group.29 This permits removal of one double bond by reduction with NADPH as shown (Eq. 17-1, step/).29a 29b The peroxisomal... 

Other compounds have been identified from the chemical compound hbrary based on the tetrahydropyridine scaffold. One example is aplexone that targets the HMG-CoA reductase pathway [27]. This compound was obtained by screening for compounds that suppress angiogenesis of... 

Park, J.H., Mangal, D., Tacka, K.A., Quinn, A.M., Harvey, R.G., Blair, I.A., and Penning, T.M. (2008) Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells. Proc. Natl. Acad. Sci. USA, 105, 6846-6851. 

The alternative reductase pathway (II in Eq. 17-1) is often faster. It makes use of an additional isomerase which converts 3-trans, 5-ds-dienoyl-CoA into the... 

In photosjmthesis, secondary pathways for electron transfer actually lead to superoxide production (9-12), the thylakoid-bound Cu2 Zn2SOD catalyzing the O2 dismutation. Because the chloroplasts lack catalase, the excess H2O2 is a substrate for ascorbate peroxidases to produce dehydroascorbate, which is further re-reduced by NADPH via the glutathione-glutathione reductase pathway (12). 

Dommes, V, Baumgart, C. Kunau, W.-H. (1981) J. Biol. Chem., 256, 8259-8262, Degradation of unsaturated fatty acids in peroxisomes. Existence of a 2,4-dienoyl-CoA reductase pathway. 

The mevalonate (MVA) pathway or mevalonic acid pathway, sometimes called HMG-CoA reductase pathway or mevalonate-dependent (MAD) route or isopren-oid pathway, is an important cellular metabolic pathway occurring in the cytosol in all higher eukaryotes and many bacteria. 

Physiological role of the lipid body LOX the reductase pathway... 

Figure L Proposed pathways for the degradation polyunsaturated fatty acids in plants. The left hand side displays the peroxisomal degradation of linoleic acid according to Gerhardt and Kleiter [9]. The left hand side shows the proposed reductase pathway.

COMMENTS ON THE DffiNOYL-CoA ISOMERASE-REDUCTASE PATHWAY VS. ENOYL-CoA ISOMERASE PATHWAY... 

Berger RG, Dettweller GR, Kollmannsberger H, Drawert F. The peroxisomal dienoyl-CoA reductase pathway in pineapple fruit. Phytochemistry 1990 29 2069-2073. 

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