Redistribution of phospholipid fatty acids

See also Glycerophospholipid Biosynthesis in Bacteria, Redistribution of Phospholipid Fatty Acids, Glycerophospholipids, Glycerophospholipid Pathway, Ether Phospholipids,... 

See also Redistribution of Phospholipid Fatty Acids, Phospholipases, Lung Surfactant, Glycerophospholipids, Second Messenger Systems... 

Redistribution of Phospholipid Fatty Acids Lung Surfactant and Phospholipases (Figure 19.6, Figure 19.7)... 

Phospholipid fatty acids may be redistributed, after they are synthesized, in response to varying environmental conditions or needs. Lung surfactant is one such phospholipid with redistributed fatty acids. Lung surfactant contains some 50% to 60% of dipalmitoylphosphatidylcholine, a form of phosphatidylcholine in which palmitoyl chains occupy both positions 1 and 2 on the glycerol. Phospholipids are usually synthesized with an unsaturated fatty acid on position 2, so some modification has likely occurred. Phospholipases may be involved in the modification, because they can remove fatty acids from phospholipids. 

On the other hand, the increased GPx activity (possibly via protein synthesis) might be associated with an oxidative stress induced by DHA (22 6, endogenous pool in the course of the DHA (22 6, -3) estoified to tri ycerides is rapidly redistributed within blood lipxqnioteins. The DHA (22 6, w-6) bound and circulate with the albumin fraction not only inhibit platelet aggregation but also influences its uptake into phospholipid species by target tissues (98). DHA therefore seems to impact platelet fatty acid metabolism through unique and novel mechanisms. 

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