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Lactate dehydrogenase (LDH, E.C. 1.1.1.27) catalyzes the reduction of pyruvate to lactate using NADH as a cofactor [Pg.295]

D. A. Barstow, T. Atkinson, A. R. Clarke, and J. J. Holbrook, A specific, highly active malate deyhdrogenase by redesign of a lactate dehydrogenase framework, Science 1988, 242, 1541-1544. [Pg.308]

The active site of lactate dehydrogenase could be redesigned to convert it to a malate dehydrogenase. (It was already known that the tertiary structures of the two enzymes were similar.) To take account of the increased... [Pg.562]

See other pages where Redesign of a Lactate Dehydrogenase is mentioned: [Pg.295] [Pg.2468] [Pg.2476] [Pg.295] [Pg.2468] [Pg.2476] [Pg.170]