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Recovery ratio approach

Dapsone (4,4 -diaminodiphenylsulfone) has been widely used for phenotyping with respect to acetylation by NAT-2 however, the drug is also N-hydroxylated. Formation of the hydroxylamine metabolite by human liver microsomes was found to be selectively mediated by CYP3A (286) this led to the development of a zero- to eight-hour urinary metabolic recovery ratio approach [dapsone hydroxylamine (dapsone + dapsone hydroxylamine)] to quantitatively assess this pathway of metabolism (287,288). Subsequently, the trait measure has been applied as part of a cocktail approach (35) in a number of studies investigating the putative role of CYP3A as a risk factor in cancer (289-291) and other disease states (288,292,293). [Pg.617]

Further support of rapid recovery of hydrological functions in secondary forest comes from the Zona Bragantina, east of Belem. Here, Holscher et al. (1997) used a Bowen ratio approach to measure evapotranspiration in a 2.5-3.5-year-old secondary forest on abandoned crop land, and found an average daily rate (3 9 mm d ) very close to that of mature forests receiving similar amounts of radiation. During the dry season, this secondary forest was absorbing water from below 3 m depth, and therefore had recovered a portion of its deep soil water uptake capacity. [Pg.150]

The CTH approach is able to control the crack width, which can be closed by controlling the compression pre-strain level. A simple equation has been established by Li et al. [54] to correlate the crack width to be closed and the pre-strain level during compression programming. Cracks with different opening widths can be closed based on the level of compression programming (of course it is limited by the maximum allowed compression pre-strain level). In the unconstrained shape recovery approach such as the SMASH approach, it has not been demonstrated that it can close a wide-opened crack with constrained boundary. Also, it cannot control the crack width that can be closed because it depends on the external load to perform programming and relies on the shape recovery ratio and boundary condition of specimens to perform crack closing. [Pg.223]

Processes with a long deadtime, more specifically processes with a large dh ratio, are relatively few. Thus most controllers, when responding to a change in SP, do not obviously benefit firom the addition of derivative action. Indeed, if the 6/z ratio is small, instability can be caused by relatively small amounts of derivative action. However we will demonstrate later that, even as the 9/x ratio approaches zero, a little derivative action can be very useful in speeding the recovery from a process disturbance. [Pg.36]

In the analysis of seawater, isotope dilution mass spectrometry offers a more accurate and precise determination than is potentially available with other conventional techniques such as flameless AAS or ASV. Instead of using external standards measured in separate experiments, an internal standard, which is an isotopically enriched form of the same element, is added to the sample. Hence, only a ratio of the spike to the common element need be measured. The quantitative recovery necessary for the flameless atomic absorption and ASV techniques is not critical to the isotope dilution approach. This factor can become quite variable in the extraction of trace metals from the salt-laden matrix of seawater. Yield may be isotopically determined by the same experiment or by the addition of a second isotopic spike after the extraction has been completed. [Pg.286]

Practical conversion processes can only approach the theoretical efficiencies shown in Table 3. The coal conversion reactions do not proceed to completion at ambient temperatures within practical time limitations. As a result, a portion of the coal feedstock must be burned to supply heat so that the reactions can be carried out at elevated temperatures and pressure where the rates of conversion are rapid. In practical systems, this additional heat can only be partially recovered. Consequently, practical conversion processes have actual heat recovery efficiencies of about 60-70% for production of high H/C ratio products. Production of secondary fuels having somewhat lower H/C ratio, i.e. about 2.0, permits attainment of heat recovery efficiencies of 70 to 80j. [Pg.304]

Since charcoal is such a good sorbent and is readily available, the solution to some sampling problems is to find a way to increase the recovery of that compound from charcoal. One way is by increasing the solvent/sorbent ratio as discussed in the phase equilibrium section. Two other approaches are the use of mixed solvents and the two-phase solvent system. [Pg.160]

Influence of the downstream plants. Up to now, we have regarded the coal gasification reactor with the waste heat recovery system as an isolated unit. In the event that the gas generated is intended to be used as fuel gas, for example in a combined power station, this approach is justified. If, however, the gas is to be used as synthesis gas, the effect of the downstream units must be taken into consideration. In such cases it is necessary to feed the gas to a CO shift conversion unit in order to obtain the C0/H2 ratio required for the synthesis process. Apart from gasification at atmospheric pressure, which requires an intermediate compression step, it has proved advisable to locate the CO shift conversion directly downstream of the gasification section. A stage in which dust particles are removed from the gas is situated between these two units. It is assumed that exergy losses do not occur in this unit. [Pg.156]

The ethylbenzene recovery rate is usually over 95 per cent, and its purity greater than 99.8 per cent. The quality of the product obtained conditions that of its derivative, the styrene monomer, and its aptitude for polymeiizatioiL This depends on the presence of toluene or other aromatics in the feed, whose content must generally not exceed 0.3 per cent This fractionation can only be calculated conveniently on a computer. The theoretic cal number of trays is as high as 330 for 95 per cent recovery. Since the efiicieocy of these trays approaches 85 per Ccnu abotH 390 real trays must be used with reflux ratios up to 80 to 90. [Pg.256]

There are other mles-of-thumb based on economic experience, which the reader will recognize, such as the optimum reflux ratio in distillation and the optimum liquid to gas ratio in gas absorption. You may also specify recoveries of key conq)onents or their concentrations in an exit stream for separators. When we use any of these rules, the assim tion is that the calculated separator size will be of reasonable cost, approximating the optimum-size separator. Similarly, for chemical reactors we may specify conversion of a desirable con jound, its exit composition or an approach temperature difference. For chemical reactors, the approach temperature difference is the difference between the actual temperature and the chemical-equilibrium ten5)erature. Again, we assume that a reactor that approximates the optimum-size reactor will result when using this rule. [Pg.104]


See other pages where Recovery ratio approach is mentioned: [Pg.586]    [Pg.620]    [Pg.586]    [Pg.64]    [Pg.124]    [Pg.30]    [Pg.80]    [Pg.206]    [Pg.222]    [Pg.359]    [Pg.388]    [Pg.137]    [Pg.139]    [Pg.89]    [Pg.190]    [Pg.648]    [Pg.146]    [Pg.665]    [Pg.766]    [Pg.253]    [Pg.354]    [Pg.383]    [Pg.119]    [Pg.235]    [Pg.528]    [Pg.395]    [Pg.242]    [Pg.270]    [Pg.390]    [Pg.239]    [Pg.35]    [Pg.533]    [Pg.586]    [Pg.601]    [Pg.190]    [Pg.624]    [Pg.161]    [Pg.115]    [Pg.174]    [Pg.473]   
See also in sourсe #XX -- [ Pg.586 , Pg.617 ]




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