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Recombinant human growth hormone aggregation

Molecular aggregation of recombinant human growth hormone (rhGH) due to air-liquid interfacial degradation can be prevented by adding polysorbate-20... [Pg.1428]

Recombinant human growth hormone (rhGH) Mannitol and glycine as amorphous excipients to prevent human growth hormone (hGH) aggregation. Trehalose as a lyoprotectant, reserves the secondary structure of rhGH. [14]... [Pg.1649]

Tavornvipas S, Tajiri S, Hirayama F, et al. (2004). Effects of hydrophilic cyclodextrins on aggregation of recombinant human growth hormone. Pharm. Res. 21 2369-2376. [Pg.410]

For liquid formulations, shaking the formulation increases the air/liquid interface in the formulation and often leads to protein denaturation. Several proteins are susceptible to denaturation by shaking, including human growth hormone (hGH) and recombinant factor XIII, both of which formed insoluble aggregates after shaking. [Pg.283]

See other pages where Recombinant human growth hormone aggregation is mentioned: [Pg.83]    [Pg.1651]    [Pg.389]    [Pg.393]    [Pg.394]    [Pg.405]    [Pg.975]    [Pg.134]    [Pg.147]    [Pg.266]    [Pg.386]    [Pg.1569]   
See also in sourсe #XX -- [ Pg.1651 ]



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