Recognition Forces and Molecular Interaction Fields MIFs

Recognition Forces and Molecular Interaction Fields (MIFs) 

The stereoelectronic features produce actions at a distance by the agency of the recognition forces they create. These forces are the hydrophobic effect, and the capacity to enter ionic bonds, van der Waals interactions and H-bonding interactions. The most convenient and informative assessment of such recognition forces is afforded by computahon in the form of MIFs, e.g. lipophilicity fields, hydrophobicity fields, molecular electrostatic potentials (MEPs) and H-bonding fields (see Chapter 6) [7-10]. 

Like the stereoelectronic features that generate them, the MIFs are highly sen-sihve to the conformahonal and ionization state of the molecule. However, they in turn have a marked intramolecular influence on the conformahonal and ionization equilibria of the compound. It is the agency of the MIFs that closes the circle of influences from molecular states to stereoelectronic features to MIFs (Fig. 1.3). 

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