Receptor target family development

LRP4 is another receptor of the LDL receptor gene family involved in regulation of embryonic patterning, mainly controlling formation of limb structures. Loss of receptor activity in gene targeted mice or spontaneous mutation in bovine cause abnormal limb development and... 

Pin, J. P, Parmentier, M. L and Prezeau, L. (2001) Positive allosteric modulators for gamma-aminobutyric acidB receptors open new routes for the development of drugs targeting family 3 G protein-coupled receptors. Mol. Pharmacol. 60, 881-884. 

Aside from providing the targets for HIV-1-induced neuropathogenesis, researchers have also studied the normal functions served by chemokines in the nervous system. One answer to this question can be obtained by considering the evolution of chemokines and their receptors. There are a large number of chemokines that have been identified to date, more than 50 in most mammals. As far as we know, all the actions of chemokines are transduced through stimulation of a family of related, G protein-coupled receptors (Tran and Miller 2003). Research into the pattern of evolution of chemokines and their receptors has revealed that a large expansion of the chemokine family occurred in parallel with the development of a sophisticated... 

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