Receptor patches

Although organo-phosphorus compounds are not directly flonoemed with the peripheral endings of sympathetic fibres we may complete the picture by noting that here adrenaline or noradrenaline are liberated and that their receptor patches are blocked by priscol and dibenamine (for formulae, see p. 41). 

Tests are made by examining the inhibition caused by the substance on the sympathomimetic effects of injected adrenaline and of sympathetic nerve stimulation. Among the recently re-oommended anti-adrenaline drugs are iminazole derivatives (e.g. priscol (VIII))2 and / -haloalkylamines (e.g. dibenamine (IX)). The action of dibenamine is almost certainly that of destroying the receptor patches in the effector organ (p. 37). 

Rodriguez JJ, Mackie K, Pickel VM (2001) Ultrastructural localization of the CBI cannabinoid receptor in mu-opioid receptor patches of the rat Caudate putamen nucleus. J Neurosci 21 823-833... 

Fig. 24. Patch and matrix striatal compartments are labeled with neurochemical markers. A) The patch compartment is labeled with 3H-naloxone binding to mu opiate receptors (white in the darkfield photomicrograph). B) The matrix compartment is labeled with calbindin-immunoreactivity, which labels spiny projection neurons that provide inputs to the substantia nigra pars reticulata. The correspondence between calbindin-poor zones (black arrows) and mu opiate binding sites (white arrows) is seen to occur in all regions of the striatum. Calbindin-immunoreactivity is relatively weak in the dorso-lateral striatum, which nonetheless contains opiate receptor patches.

Receptors or signal transducers for secreted hormones or developmental signals that Inhibit cell proliferation (e.g., TGFp, the hedgehog receptor patched)... 

Receptor PATCHED Cell membrane Basal cell carcinoma... 

Kayed, H, Kleeff, J, Keleg, S, Buchler, MW, and Friess, H, Distribution of Indian hedgehog and its receptors patched and smoothened in human chronic pancreatitis,... 

ShhN, the 20 kDa A-terminal fragment of Shh, functions by binding to its transmembrane receptor. Patched (Ptcl). This interaction prevents Patched s inhibition of Smoothened (Smo), thus allowing Smoothened to activate processes within the cell (Figure TUB). 

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