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Receptor dependent endogenous triggers

Preischemic activation of a-adrenergic signaling also results in cardioprotection. Pretreatment with norepinephrine induces bimodal (early and delayed) myocardial functional adaptation to ischemia in rats. PKC appears to be involved in the early response. Delayed protection was shown to be associated with the expression of genes encoding fetal contractile proteins (increase in P-MHC mRNA).94 However, a-receptor agonists can trigger arrhythmias in the setting of ischemia and reperfusion.55 [Pg.34]

Prostacyclin is increased in response to ischemia and reperfusion through activation of the cyclooxygenase-2 pathway. Inhibition of cyclooxygenase-2 by celecoxib or meloxicam resulted in a concentration dependent exacerbation of the myocardial dysfunction and damage in a perfused rabbit heart model of ischemia and reperfusion, indicating a cardioprotective role for prostacyclin.104 [Pg.35]

Histamine is released in the setting of ischemia and reperfusion. The mast cell degranulates during ischemia and the wash out of mast cells releases histamine dur- [Pg.35]

See other pages where Receptor dependent endogenous triggers is mentioned: [Pg.34]    [Pg.34]    [Pg.222]    [Pg.366]    [Pg.337]    [Pg.194]    [Pg.247]    [Pg.380]    [Pg.198]    [Pg.45]    [Pg.265]    [Pg.283]    [Pg.287]    [Pg.170]    [Pg.2661]    [Pg.579]    [Pg.450]    [Pg.73]    [Pg.93]   


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