Receptor agonists examples

Another type of anxiolytic is buspirone, which appears to work principally as a partial agonist at 5-HTia receptors (see 5-HYDROXYTRYPTAMINE receptor agonists). Examples under development include tandospirone, zalospirone and zolmitriptan. 

Hydroxylated 2-aminotetralins are potent dopamine receptor agonists. Examples of such are 5-hydroxy-2-(N,N-di- -propylamino)tetralin (5-OH-DPAT, 9)98,100,205 and 7-hydroxy-2-(N,N-di-w-propylamino)tetralin (7-OH-DPAT, 10) 79,213 These compounds have no clinical utility because of their low oral bioavailability and their short duration of action, due to glucuronidation in the liver and gut.161 We have synthesised and tested 6-(N,N-di-//-propyl)amino-4,5,6,7-tetrahydrobenzo[ ]thiophene (34) and 5-(N,N-di-/ -propyl )ami no-4,5,6,7-tetrahydrobenzo[/i]thiophene (35), which are thiophene analogues of hydroxylated 2-aminotetralins. These tetrahydrobenzo[/)]thiophenes turned out to possess a higher relative oral bioavailability than 5-OH-DPAT (chapter 4 and ref. 215). However, the affinity for the dopamine receptors is diminished, as compared to 5-OH-DPAT (chapter 2, ref. 239). 

A medication that causes induction of sleep. The majority of currently available hypnotics (for example benzodiazepine receptor agonists) act via potentiating the brain s inhibitory GABAergic systems, in turn reducing the activity of arousal (i.e. wake promoting) neurotransmitter systems. 

Examples of sympathomimetic bronchodilators include albuterol (Ventolin), epinephrine (Adrenalin), salme-terol (Serevent), and terbutaline (Brethine). Many of the sympathomimetics used as bronchodilators have die subclassification of beta-2 ((32) receptor agonists (eg, albuterol, salmeterol, and terbutaline). Additional information concerning the various sympathomimetic dragp is given in the Summary Drug Table Bronchodilators. 

In another example from the literature [40], we see a strong correlation between potency and PSA. In this case a series of 53 CCR5 receptor agonists have been... 

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